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A DECADE OF RIGHT LIVER ADULT-TO-ADULT LIVE DONOR LIVER TRANSPLANTATION: MID-TERM OUTCOMES

See Ching Chan, Barbara Chik, Chi Leung Liu, Chung Mau Lo, Sheung Tat Fan. Hepato Biliary Pancreatic Surgery, Dep. of Surgery, University of Hong Kong Medical Center, Hong Kong, Hong Kong

Introduction
  Right liver adult-to-adult live donor liver transplantation debuted a decade ago is now due for mid-term outcomes appraisal.
Patients and methods
  Consecutive liver transplant cases with a minimum follow-up of 2 years in Queen Mary Hospital, the University of Hong Kong from May 1996 to December 2004 were included (N=188). The data including recipient and graft characteristics were collected prospectively and were analyzed retrospectively. From 1996 to 2000, fewer than 30 cases per year were determined early era.
Results
  This series had a median followup of 48 months. The early era included 28 cases and the latter era 160 cases. Recipients of the early era were slightly younger (42 yr vs. 48 yr, p = 0.002) and fewer of them suffered from hepatocellular carcinoma (HCC) (10.7% vs. 29.4%, p = 0.039). Disease severity was worse as reflected by a higher proportion of recipients with hepatorenal syndrome (35.7% vs. 16.3%, p = 0.016), and higher Model of End-stage Liver Disease scores (34 vs. 26, p = 0.007). Graft characteristics were similar. The recipients of the early era had higher hospital mortalities (6/28 vs. 4/160, p = 0.001). Transplantation in the high urgency situation did not result in higher hospital mortality (5/91 vs. 5/97, p = 0.917). None of the recipients transplanted for HCC had hospital mortality (0/50 vs. 10/138, p = 0.065). On univariate analysis, the presence of HCC and transplantation in the early era were of adverse factors for survival. This was verified by a multivariate analysis which indicated that early era (RR = 2.824, p = 0.015) and HCC (RR = 2.897, p = 0.005) were factors adversely affecting overall survival.
  The 1-, 3-, and 5-year overall survivals were 92.5%, 86.3%, and 82.3%, respectively. When recipients with hospital mortality and transplanted for HCC were excluded, the 1-, 3-, and 5-year overall survivals became 97.6%, 95.3%, and 95.3%, respectively. Recipients with HCC (n = 50) and only those who were within the Milan criteria (n = 34) had 1-, 3-, and 5-year survivals of 98.0%, 80.5%, and 63.4%; and 97.1%, 85.0%, and, 67.6%, respectively.
Conclusion
  This operation resulted in predictably high 5-year survival in particular when hospital mortality could be avoided after maturation of techniques and careful case selection of recipients with a low chance of recurrence from HCC.

 
 
   
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